Usage of telemedicine has grown in recent years, but its adoption has been slowed in part by regulatory policy. For instance, healthcare professionals must be licensed in the state that the patient is physically located. The Nurse Licensure Compact (NLC) allows RNs to practice in any compact state on one state license, which makes it easier to provide telemedicine—one of the goals of the NLC. Using 2019 insurance claims data from Change Healthcare, we compare telemedicine usage in states that have adopted the NLC to those that have not. On average, NLC states had a slightly higher average percentage of telemedicine usage from out-of-state providers, but the differences were not statistically significant.